Hypovitaminosis D and chronic pain

Pediatric Hypovitaminosis D

Vitamin D, a secosteroid, is essential for the development and maintenance of healthy bone in both the adult and pediatric populations. Low level of 25-hydroxy vitamin D (25-(OH)-D) is highly prevalent in children worldwide and has been linked to various adverse health outcomes including rickets, osteomalacia, osteomalacic myopathy, sarcopenia, and weakness, growth retardation, hypocalcemia, se...

Vitamin D and chronic pain.

A number of studies have suggested a link between low levels of vitamin D and higher incidence of chronic pain [4,7,22]. There is a well-established link between low vitamin D and pain due to osteomalacia. There is no clear biological mechanism of how low vitamin D might be causally related to other types of chronic pain, though vitamin D is thought to be involved in regulating inflammatory cyt...

Hypovitaminosis D in healthy schoolchildren.

BACKGROUND Vitamin D is essential for skeletal growth, but there are currently no guidelines for vitamin D supplementation after infancy. This study investigates vitamin D insufficiency in healthy children. METHODS Children ages 10 to 16 years from 3 private schools in Beirut, Lebanon, with differing socioeconomic status (SES) were studied: 169 in the spring of 1999 and 177 in the following f...

Hypovitaminosis D in systemic sclerosis.

Is Serum Hypovitaminosis D Associated with Chronic Widespread Pain Including Fibromyalgia? A Meta-analysis of Observational Studies.

BACKGROUND Chronic widespread pain (CWP) is a global musculoskeletal disorder leading to disability and a reduced quality of life. Low levels of serum vitamin D has long been proposed to be associated with CWP, but previous research remains inconclusive. OBJECTIVES To determine whether hypovitaminosis D was independently associated with CWP. STUDY DESIGN Meta-analysis of observational study...